MiR-206 regulates the Th17/Treg ratio during osteoarthritis.

ABSTRACT:

Background

The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).

Methods

Patients with OA and healthy controls were recruited for investigating the association between miR-206 and Th17/Treg ratio. Transfection experiments were conducted in CD4⁺ T cells to verify the mechanism of miR-206 on the balance of Treg/Th17. OA model was constructed to detect the clinical score, histopathological changes and Treg/Th17 ratio. OA model was induced in rats to verify the effect of miR-206 inhibition on Th17/Treg immunoregulation.

Results

High expression of miR-206 was positively correlated with peripheral Th17/Treg imbalance in patients with OA. The

SUBMITTER: Ye X 

PROVIDER: S-EPMC8214293 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature