Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization.

ABSTRACT:

Background

Vulnerability to COVID-19 hospitalization has been linked to behavioral risk factors, including combustible psychoactive substance use (e.g., tobacco smoking). Paralleling the COVID-19 pandemic crisis have been increasingly permissive laws for recreational cannabis use. Cannabis use disorder (CUD) is a psychiatric disorder that is heritable and genetically correlated with respiratory disease, independent of tobacco smoking. We examined the genetic relationship between CUD and COVID-19 hospitalization.

Methods

We estimated the genetic correlation between CUD (case: n = 14,080; control: n = 343,726) and COVID-19 hospitalization (case: n = 9373; control: n = 1,197,256) using summary statistics from genome-wide association studies. Using in

SUBMITTER: Hatoum AS 

PROVIDER: S-EPMC8214324 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature