Task-specific interhemispheric hypoconnectivity in writer's cramp - An EEG study.

ABSTRACT:

Objective

Writer's cramp (WC) is a focal task-specific dystonia characterized by abnormal posturing of the hand muscles during handwriting, but not during other tasks that involve the same set of muscles and objects such as sharpening a pencil. Our objective was to investigate the pathophysiology underlying the task specificity of this disorder using EEG. We hypothesized that premotor-parietal connectivity will be lower in WC patients specifically during handwriting and motor imagery of handwriting.

Methods

We recruited 15 WC patients and 15 healthy controls. EEG was recorded while participants performed 4 tasks - writing with a pencil, sharpening a pencil, imagining writing and imagining sharpening. We determined the connectivity changes between relevant brain regions durin

SUBMITTER: Thirugnanasambandam N 

PROVIDER: S-EPMC8214401 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature