Activity in orbitofrontal neuronal ensembles reflects inhibitory control.

ABSTRACT: Stopping, or inhibition, is a form of self-control that is a core element of flexible and adaptive behavior. Its neural origins remain unclear. Some views hold that inhibition decisions reflect the aggregation of widespread and diverse pieces of information, including information arising in ostensible core reward regions (i.e., outside the canonical executive system). We recorded activity of single neurons in the orbitofrontal cortex (OFC) of macaques, a region associated with economic decisions, and whose role in inhibition is debated. Subjects performed a classic inhibition task known as the stop signal task. Ensemble decoding analyses reveal a clear firing rate pattern that distinguishes successful from failed inhibition and that begins after the stop signal and before the stop signal r

SUBMITTER: Balasubramani PP 

PROVIDER: S-EPMC8214402 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature