Starvation-Sensitized and Oxygenation-Promoted Tumor Sonodynamic Therapy by a Cascade Enzymatic Approach.

ABSTRACT: The therapeutic outcomes of noninvasive sonodynamic therapy (SDT) are always compromised by tumor hypoxia, as well as inherent protective mechanisms of tumor. Herein, we report a simple cascade enzymatic approach of the concurrent glucose depletion and intratumoral oxygenation for starvation-sensitized and oxygenation-amplified sonodynamic therapy using a dual enzyme and sonosensitizer-loaded nanomedicine designated as GOD/CAT@ZPF-Lips. In particular, glucose oxidase- (GOD-) catalyzed glycolysis would cut off glucose supply within the tumor, resulting in the production of tumor hydrogen peroxide (H₂O₂) while causing tumor cells starvation. The generated H₂O₂ could subsequently be decomposed by catalase (CAT) to generate oxygen, which acts as reac

SUBMITTER: Wu W 

PROVIDER: S-EPMC8214509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature