Evaluating the Association between CCR5delta32 Polymorphism (rs333) and the Risk of Breast Cancer in a Cohort of Iranian Population.

ABSTRACT:

Background

CC chemokine receptor 5 (CCR5) is introduced as an immune response modulator. The activity of CCR5 influences breast tumour development in a p53-dependent manner. This study aimed to investigate the frequency of CCR5delta32 and its association with the risk of breast cancer in 1038 blood samples in North East of Iran.

Methods

In this case-control study, we genotyped 570 control samples and 468 breast cancer patients by a gel electrophoresis-based gap-polymerase chain reaction (gap-PCR) method Mashhad, Iran. The data were analyzed using the SPSS software.

Results

Of 570 controls included, 542 (95.09%) had CCR5delta32 ^{wild/wild (W/W)} genotype, 28 samples (4.91%) had CCR5delta32 ^{wild/deletion (W/D)} genotype and

SUBMITTER: Tajbakhsh A 

PROVIDER: S-EPMC8214612 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature