Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to be the leading cause of chronic liver disease worldwide. This study aims to systematically review and meta-analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver.

Methods

Following a systematic review and meta-analysis method, articles without any time limitation, were extracted from SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed and ScienceDirect international databases. Random effects model was used for analysis, and heterogeneity of studies was investigated considering the I² index and using Comprehensive Meta-Analysis software.

Results

The odds ratio of CC genotype in patients with non-alcoholic fatty liver

SUBMITTER: Salari N 

PROVIDER: S-EPMC8214766 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature