Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.

ABSTRACT:

Background

Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly.

Methods

Our study included 3 family-based ascertainments: LLFS (Long Life Family Study, N_Individuals=4572), which represents a low CHD risk, and Family Heart Study, which consists of randomly selected families (FamHS-random, N_Individuals=1806), and high CHD risk families (FamHS-high risk, N_Individuals=2301). We examined the effects of PRS, sex, family ascertainment, PRS interaction with sex (PRS*sex) and with family ascertainment (PRS*LLFS and PRS*FamHS-high risk) on CHD, corrected for tra

SUBMITTER: Feitosa MF 

PROVIDER: S-EPMC8214825 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature