Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents.

ABSTRACT:

Purpose

Patients with Fontan circulation are at risk of developing hepatic fibrosis/cirrhosis. The mechanisms and disease development are unclear and early secondary liver cancer is a concern. This study will describe hepatic imaging findings in a national cohort of adolescents with Fontan circulation.

Methods

The patients prospectively underwent abdominal contrast enhanced magnetic resonance imaging (MRI) including diffusion-weighted imaging. Images were assessed for criteria of fibrosis/cirrhosis including characterization of hepatic nodules. These nodules were in addition, assessed by ultrasonography (US). Nodules ≥ 1 cm were investigated and monitored to evaluate malignant transformation. Clinical and hepatic serological data were recorded.

Results

Forty-six patie

SUBMITTER: Thrane KJ 

PROVIDER: S-EPMC8215034 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature