Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin.

ABSTRACT: The purpose of this study was to explore the skin transcriptional profile in pediatric localized scleroderma (LS) to provide a better understanding of the altered immune and fibrotic pathways promoting disease. LS is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children. RNA sequencing (RNAseq) technology allows for improved understanding of relevant cellular expression through transcriptome analysis of phases during LS disease progression (more active/inflammatory vs. inactive/fibrotic) and also permits the use of RNA extracted from existing paraffin-embedded skin tissue, which is important in pediatrics. A strong correlation was observed between the comparison of genes expressed between f

SUBMITTER: Mirizio E 

PROVIDER: S-EPMC8215272 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature