Selective digestive decontamination with oral colistin plus gentamicin for persistent bacteraemia caused by non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae in a neutropenic patient.

ABSTRACT:

Background

Carbapenem-resistant Klebsiella pneumoniae (CRKp) have become an increasing public health problem worldwide. While most CRKp around the world harbour a carbapenemase enzyme, the clinical relevance of non-carbapenemase-producing CRKp (non-CP-CRKp) is increasingly recognized. Selective digestive decontamination (SDD) has been proven successful as a decolonization strategy for patients colonized with Gram-negatives in the ICU. However, it is not regularly used to treat invasive infections.

Objectives

To report the use of SDD as a useful strategy for managing recalcitrant CRKp bloodstream infections.

Patients and methods

We present a neutropenic patient with a recalcitrant bloodstream infection with non-CP-CRKp t

SUBMITTER: Spencer-Sandino M 

PROVIDER: S-EPMC8215431 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature