Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related to systemic inflammation is still unsettled. While the implication of microglia is well recognized, the exact contribution of peripheral monocytes/macrophages is still largely unknown, especially concerning their role in the various stages of AD.

Objectives

AD develops over decades and its clinical manifestation is preceded by subjective memory complaints (SMC) and mild cognitive impairment (MCI); thus, the question arises how the peripheral innate immune response changes with the progression of the disease. Therefore, to further investigate the roles of mon

SUBMITTER: Munawara U 

PROVIDER: S-EPMC8215492 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature