A Robust Multiscale and Multiphasic Structure-Based Modeling Framework for the Intervertebral Disc.

ABSTRACT: A comprehensive understanding of multiscale and multiphasic intervertebral disc mechanics is crucial for designing advanced tissue engineered structures aiming to recapitulate native tissue behavior. The bovine caudal disc is a commonly used human disc analog due to its availability, large disc height and area, and similarities in biochemical and mechanical properties to the human disc. Because of challenges in directly measuring subtissue-level mechanics, such as in situ fiber mechanics, finite element models have been widely employed in spinal biomechanics research. However, many previous models use homogenization theory and describe each model element as a homogenized combination of fibers and the extrafibrillar matrix while ignoring the role of water content or osmotic behavior.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC8215504 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature