Identification of a Genome Instability-Associated LncRNA Signature for Prognosis Prediction in Colon Cancer.

ABSTRACT: Long non-coding RNAs (lncRNAs) were reported to have the potential in maintaining genome instability, but the identification of lncRNAs related to genome instability and their prognostic value have not been largely explored in colon cancer. In this study, we obtained 155 genome instability-associated lncRNAs based on somatic mutation profiles in colon cancer from The Cancer Genome Atlas (TCGA) database. Functional enrichment analysis revealed the possible roles of genes co-expressed with those lncRNAs involved in some cancer, genome instability and immune related biological processes. Combined with overall survival data, a seven-lncRNA signature was established for prognosis prediction. According to the risk score calculated by this signature, high-risk patients characterized by high somat

SUBMITTER: Yin T 

PROVIDER: S-EPMC8215581 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature