Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology.

ABSTRACT:

Purpose of review

This review summarizes the significant biophysical and rheological aspects of red blood cell physiology and pathophysiology in relation to recent advances in microfluidic biomarker assays and emerging targeted or curative intent therapies.

Recent findings

Alterations in red cell biophysical properties and blood rheology have been associated with numerous hematologic and circulatory disorders. Recent advances in biomarker assays enable effective assessment of these biophysical and rheological properties in normoxia or physiological hypoxia in a clinically meaningful way. There are emerging targeted or curative therapies that aim to improve red cell pathophysiology, especially in the context of inherited hemoglobin disorders, such as sickle cell disease.

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SUBMITTER: Gurkan UA 

PROVIDER: S-EPMC8215585 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature