Circulating Cytokines and Coronavirus Disease: A Bi-Directional Mendelian Randomization Study.

ABSTRACT:

Background

Immune system functioning is relevant to vulnerability to coronavirus disease (COVID-19). Cytokines are important to immunity. To further elucidate the role of the immune system in COVID-19, we used Mendelian randomization (MR) to assess comprehensively and bi-directionally the role of cytokines in COVID-19.

Methods

We assessed primarily whether genetically different levels of 41 cytokines affected risk of any COVID-19 (laboratory confirmed, physician confirmed or self-reported, 36,590 cases, 1,668,938 controls), and conversely if genetic risk of liability to any COVID-19 affected these cytokines (n ≤ 8293) using the most recent genome-wide association studies. We obtained inverse variance weighting (IVW) estimates, conducted sensitivity analyses and used a

SUBMITTER: Li M 

PROVIDER: S-EPMC8215612 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature