LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence.

ABSTRACT:

Background

Mutations in the serine/threonine kinase 11 (STK11)/liver kinase B1 (LKB1) have been implicated in mediating resistance to checkpoint blockade among patients with advanced lung adenocarcinoma. We sought to examine the associations between clinicopathologic characteristics, tumor LKB1 expression, features of the immune microenvironment, and postoperative prognosis among patients with early stage lung adenocarcinoma undergoing surgical therapy.

Methods

Formalin-fixed, paraffin-embedded specimens of patients undergoing resection of stage I to III, chemotherapy-naïve adenocarcinomas (1997 to 2008) were analyzed using tissue microarray sectioning. Sublobar resections were excluded. Intratumoral LKB1/STK11 expression was quantified as H-score. In a subset, tumor-associa

SUBMITTER: Mitchell KG 

PROVIDER: S-EPMC8215648 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature