Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances.

ABSTRACT: Endocrine-disrupting substances (EDS) may have certain biological effects including delayed effects, multigenerational effects, and may display nonmonotonic dose-response (NMDR) relationships that require careful consideration when determining environmental hazards. Endocrine disrupting substances can have specific and profound effects when exposure occurs during sensitive windows of the life cycle (development, reproduction). This creates the potential for delayed effects that manifest when exposure has ceased, possibly in a different life stage. This potential underscores the need for testing in appropriate (sensitive) life stages and full life cycle designs. Such tests are available in the Organisation for Economic Co-operation and Development (OECD) tool box and should be used to deriv

SUBMITTER: Parrott JL 

PROVIDER: S-EPMC8215718 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature