Atherosclerotic cardiovascular disease events among statin eligible individuals with and without long-term healthy arterial aging.

ABSTRACT:

Background and aims

A large proportion of statin eligible candidates have a baseline absence of coronary artery calcium (CAC) and low 10-year atherosclerotic cardiovascular disease (ASCVD) risk. We sought to determine the proportion of statin eligible individuals who had long-term healthy arterial aging (persistent CAC = 0) and their examined 15-year ASCVD outcomes.

Methods

We included 561 statin eligible candidates from the Multi-Ethnic Study of Atherosclerosis who were not on statin therapy with CAC = 0 at Visit 1 (2000-02) and underwent a subsequent CAC scan at Visit 5 (2010-11). Adjusted Cox proportional hazards regression assessed the association between persistent CAC = 0 and ASCVD events over 15.9 years.

Results

Participants were on average 61.7 years old, 50%

SUBMITTER: Razavi AC 

PROVIDER: S-EPMC8215721 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature