RTP4 is a novel prognosis-related hub gene in cutaneous melanoma.

ABSTRACT:

Objective

Melanoma accounts for 80% of skin cancer deaths. The pathogenesis of melanoma is regulated by gene networks. Thus, we aimed here to identify gene networks and hub genes associated with melanoma and to further identify their underlying mechanisms.

Methods

GTEx (normal skin) and TCGA (melanoma tumor) RNA-seq datasets were employed for this purpose. We conducted weighted gene co-expression network analysis (WGCNA) to identify key modules and hub genes associated with melanoma. Log-rank analysis and multivariate Cox model analysis were performed to identify prognosis genes, which were validated using two independent melanoma datasets. We also evaluated the correlation between prognostic gene and immune cell infiltration.

Results

The blue module was the most rele

SUBMITTER: Li Y 

PROVIDER: S-EPMC8215788 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature