Genomic epidemiology of methicillin-resistant and -susceptible Staphylococcus aureus from bloodstream infections.

ABSTRACT:

Background

Bloodstream infections due to Staphylococcus aureus cause significant patient morbidity and mortality worldwide. Of major concern is the emergence and spread of methicillin-resistant S. aureus (MRSA) in bloodstream infections, which are associated with therapeutic failure and increased mortality.

Methods

We generated high quality draft genomes from 323 S. aureus blood culture isolates from patients diagnosed with bloodstream infection at the Dartmouth-Hitchcock Medical Center, New Hampshire, USA in 2010-2018.

Results

In silico detection of antimicrobial resistance genes revealed that 133/323 isolates (41.18%) carry horizontally acquired genes conferring resistance to at least three antimicrobial classes, with resistance determinants for aminoglycosides, bet

SUBMITTER: Smith JT 

PROVIDER: S-EPMC8215799 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature