Regulatory annotation of genomic intervals based on tissue-specific expression QTLs.

ABSTRACT:

Motivation

Annotating a given genomic locus or a set of genomic loci is an important yet challenging task. This is especially true for the non-coding part of the genome which is enormous yet poorly understood. Since gene set enrichment analyses have demonstrated to be effective approach to annotate a set of genes, the same idea can be extended to explore the enrichment of functional elements or features in a set of genomic intervals to reveal potential functional connections.

Results

In this study, we describe a novel computational strategy named loci2path that takes advantage of the newly emerged, genome-wide and tissue-specific expression quantitative trait loci (eQTL) information to help annotate a set of genomic intervals in terms of transcription regulation. By checking

SUBMITTER: Xu T 

PROVIDER: S-EPMC8215915 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature