High Prevalence of Hearing Impairment in Primary Congenital Hypothyroidism.

ABSTRACT:

Background

An association between hearing impairment (HI) and congenital hypothyroidism (CH) has been reported previously. However, in general, studies were retrospective and had small sample sizes, and the results were variable and inconclusive. The aim of our study was to assess the prevalence of HI among patients with CH and to examine factors potentially predictive of HI including severity of CH, etiology of CH, and timing of treatment initiation.

Methods

Audiometry was undertaken prospectively in 66 patients aged 3-21 years diagnosed with primary CH and 49 healthy matched controls. All patients with HI underwent examination by an otolaryngologist, and in patients with sensorineural loss, brainstem evoked response audiometry was performed. A next-generation sequencing (N

SUBMITTER: Almagor T 

PROVIDER: S-EPMC8216036 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature