Electrochemical safety limits for clinical stimulation investigated using depth and strip electrodes in the pig brain.

ABSTRACT: Objective. Diagnostic and therapeutic electrical stimulation are increasingly utilized with the rise of neuromodulation devices. However, systematic investigations that depict the practical clinical stimulation paradigms (bipolar, two-electrode configuration) to determine the safety limits are currently lacking. Further, safe charge densities that were classically determined from conical sharp electrodes are generalized for cylindrical (depth) and flat (surface grid) electrodes completely ignoring geometric factors that govern current spreading and trajectories in tissue.Approach. This work reports the first investigations comparing stimulation limits for clinically used electrodes in two mediums: in benchtop experiments in saline andin vivoin a single acute experiment

SUBMITTER: Vatsyayan R 

PROVIDER: S-EPMC8216108 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature