Depinar, a drug that potentially inhibits the binding and entry of COVID-19 into host cells based on computer-aided studies.

ABSTRACT:

Background and purpose

The new coronavirus (Covid-19) has resulted in great global concerns. Due to the mortality of this virus, scientists from all over the world have been trying to employ different strategies to tackle down this concern. This virus enters cells via phagocytosis through binding to the angiotensin-converting enzyme II receptor. After invading the body, it can stay hidden in there for a period of up to 24 days (incubation period).

Experimental approach

In this report, by the use of in silico studies we selected several FDA-approved compounds that possess antiviral properties. We chose the viral Spike protein as the target of drug compounds and carried out the screening process for the FDA databank in order to find the most effective ligand.

SUBMITTER: Yazdani M 

PROVIDER: S-EPMC8216164 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature