DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles.

ABSTRACT: The interaction of CNS tumors with infiltrating lymphocytes plays an important role in their initiation and progression and might be related to therapeutic responses. Gene expression-based methods have been successfully used to characterize the tumor microenvironment. However, methylation data are now increasingly used for molecular diagnostics and there are currently only few methods to infer information about the microenvironment from this data type. Using an approach based on differential methylation and principal component analysis, we developed DIMEimmune (Differential Methylation Analysis for Immune Cell Estimation) to estimate CD4⁺ and CD8⁺ T cell abundance as well as tumor-infiltrating lymphocytes (TILs) scores from bulk methylation data. Well-established appr

SUBMITTER: Safaei S 

PROVIDER: S-EPMC8216185 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature