Birth weight associations with DNA methylation differences in an adult population.

ABSTRACT: The Developmental Origins of Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience and has been associated with multiple adult health outcomes. DNA methylation (DNAm) is one plausible mechanism behind the relationship of birth weight to adult health. Through data linkage between Generation Scotland and historic Scottish birth cohorts, and birth records held through the NHS Information and Statistics Division, a sample of 1,757 individuals with available birth weight and DNAm data was derived. Epigenome-wide association studies (EWAS) were performed in two independently generated DNAm subgroups (n_Set1 = 1,395, n_Set2 = 362), relating adult DNAm from whole bl

SUBMITTER: Madden RA 

PROVIDER: S-EPMC8216207 | biostudies-literature | 2021 Jun-Jul

REPOSITORIES: biostudies-literature