Orientation of Temporal Interference for Non-invasive Deep Brain Stimulation in Epilepsy.

ABSTRACT: In patients with focal drug-resistant epilepsy, electrical stimulation from intracranial electrodes is frequently used for the localization of seizure onset zones and related pathological networks. The ability of electrically stimulated tissue to generate beta and gamma range oscillations, called rapid-discharges, is a frequent indication of an epileptogenic zone. However, a limit of intracranial stimulation is the fixed physical location and number of implanted electrodes, leaving numerous clinically and functionally relevant brain regions unexplored. Here, we demonstrate an alternative technique relying exclusively on non-penetrating surface electrodes, namely an orientation-tunable form of temporally interfering (TI) electric fields to target the CA3 of the mouse hippocampus which focal

SUBMITTER: Missey F 

PROVIDER: S-EPMC8216218 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature