Baseline Variables Associated with Functional Decline in 2CARE, A Randomized Clinical Trial in Huntington's Disease.

ABSTRACT:

Background

Despite the clearly recognized progressive functional decline of Huntington's disease (HD), detailed investigations of factors associated with the rate of functional progression are limited.

Objective

Understanding factors associated with functional decline through examination of existing HD clinical databases may improve efforts to mitigate it.

Methods

We analyzed data from 2CARE, a randomized clinical trial with up to 5 years of follow-up, to assess potential risk factors for more rapid functional decline in HD.

Results

Variables associated with faster functional decline included worse motor performance, worse cognitive test scores, female sex, lower weight and body mass index, and a higher CAG repeat length, especially in younger people.

Conclu

SUBMITTER: McGarry A 

PROVIDER: S-EPMC8216232 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature