Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry.

ABSTRACT:

Objective

This study aimed to use cluster analysis (CA) to identify different clinical phenotypes among antiphospholipid antibodies (aPL)-positive patients.

Methods

The Alliance for Clinical Trials and International Networking (APS ACTION) Registry includes persistently positive aPL of any isotype based on the Sydney antiphospholipid syndrome (APS) classification criteria. We performed CA on the baseline characteristics collected retrospectively at the time of the registry entry of the first 500 patients included in the registry. A total of 30 clinical data points were included in the primary CA to cover the broad spectrum of aPL-positive patients.

Results

A total of 497 patients from international centres were analysed, resulting in three main exclusive clusters: (a)

SUBMITTER: Zuily S 

PROVIDER: S-EPMC8216235 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature