RNAMotifContrast: a method to discover and visualize RNA structural motif subfamilies.

ABSTRACT: Understanding the 3D structural properties of RNAs will play a critical role in identifying their functional characteristics and designing new RNAs for RNA-based therapeutics and nanotechnology. While several existing computational methods can help in the analysis of RNA properties by recognizing structural motifs, they do not provide the means to compare and contrast those motifs extensively. We have developed a new method, RNAMotifContrast, which focuses on analyzing the similarities and variations of RNA structural motif characteristics. In this method, a graph is formed to represent the similarities among motifs, and a new traversal algorithm is applied to generate visualizations of their structural properties. Analyzing the structural features among motifs, we have recognized and gene

SUBMITTER: Islam S 

PROVIDER: S-EPMC8216276 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature