Tissue- and stage-specific landscape of the mouse translatome.

ABSTRACT: The current understanding of how overall principles of translational control govern the embryo-to-adult transition in mammals is still far from comprehensive. Herein we profiled the translatomes and transcriptomes of six tissues from the mice at embryonic and adult stages and presented the first report of tissue- and stage-specific translational landscape in mice. We quantified the extent of gene expression divergence among different expression layers, tissues and stages, detected significant changes in gene composition and function underlying these divergences and revealed the changing architecture of translational regulation. We further showed that dynamic translational regulation can be largely achieved via modulation of translational efficiency. Translational efficiency could be altere

SUBMITTER: Wang H 

PROVIDER: S-EPMC8216458 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature