Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) is a common disease that is characterized by multiple inflammatory endotypes. However, the molecular mechanisms in CRSsNP are poorly understood compared with those of polypoid CRS.

Objective

Our aim was to identify mechanisms and biomarkers associated with inflammatory endotypes underpinning CRSsNP.

Methods

Ethmoid tissues and nasal lavage fluids (NLFs) were obtained from control patients and patients with CRS. The gene expression profiles were determined by microarray analysis and quantitative RT-PCR, and expression of proteins was measured by ELISA and Luminex analysis.

Results

Microarray found that compared with their levels of expression in control tissue, the levels of expression of 126,

SUBMITTER: Klingler AI 

PROVIDER: S-EPMC8216505 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature