Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation.

ABSTRACT: The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ~ 80% asymptomatic or mild cases and ~ 5% severe cases. Recent genome-wide association studies (GWAS) have identified several genetic loci associated with the severe COVID-19 symptoms. Delineating the genetic variants and genes is important for better understanding its biological mechanisms. We implemented integrative approaches, including transcriptome-wide association studies (TWAS), colocalization analysis, and functional element prediction analysis, to interpret the genetic risks using two independent GWAS datasets in lung and immune cells. To understand the context-specific molecular alteration, we further performed deep learning-based single-cell transcriptomic analys

SUBMITTER: Dai Y 

PROVIDER: S-EPMC8216591 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature