Detection of Postcolonoscopy Colorectal Neoplasia by Multi-target Stool DNA.

ABSTRACT:

Introduction

Significant variability between colonoscopy operators contributes to postcolonoscopy colorectal cancers (CRCs). We aimed to estimate postcolonoscopy colorectal neoplasia (CRN) detection by multi-target stool DNA (mt-sDNA), which has not previously been studied for this purpose.

Methods

In a retrospective cohort of patients with +mt-sDNA and completed follow-up colonoscopy, positive predictive value (PPV) for endpoints of any CRN, advanced adenoma, right-sided neoplasia, sessile serrated polyps (SSP), and CRC were stratified by the time since previous colonoscopy (0-9, 10, and ≥11 years). mt-sDNA PPV at ≤9 years from previous average-risk screening colonoscopy was used to estimate CRN missed at previous screening colonoscopy.

Results

Among the 850 studied

SUBMITTER: Ebner DW 

PROVIDER: S-EPMC8216679 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature