Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases.

ABSTRACT: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Genome-wide association studies (GWAS) are powerful epidemiological tools to find genes and variants associated with cardiovascular diseases while follow-up biological studies allow to better understand the etiology and mechanisms of disease and assign causality. Improved methodologies and reduced costs have allowed wider use of bulk and single-cell RNA sequencing, human-induced pluripotent stem cells, organoids, metabolomics, epigenomics, and novel animal models in conjunction with GWAS. In this review, we feature recent advancements relevant to cardiovascular diseases arising from the integration of genetic findings with multiple enabling technologies within multidisciplinary teams to highlight the solidi

SUBMITTER: Lu H 

PROVIDER: S-EPMC8216854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature