Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants.

ABSTRACT:

Background and purpose

To determine whether neurofilament light chain (NfL), a promising serum and cerebrospinal fluid (CSF) biomarker of neuroaxonal damage, predicts functional outcome in preterm infants with neonatal brain injury.

Methods

Our prospective observational study used a sensitive single-molecule array assay to measure serum and CSF NfL concentrations in preterm infants with moderate to severe peri/intraventricular hemorrhage (PIVH). We determined temporal serum and CSF NfL profiles from the initial diagnosis of PIVH until term-equivalent age and their association with clinical and neurodevelopmental outcome until 2 years of age assessed by Bayley Scales of Infant Development (3rd edition). We fitted univariate and multivariate logistic regression models to deter

SUBMITTER: Goeral K 

PROVIDER: S-EPMC8217001 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature