Cherry-picking the Wrong Patients?
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ABSTRACT:
SUBMITTER: Fiehler J
PROVIDER: S-EPMC8217008 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Cherry-picking the Wrong Patients?
Fiehler Jens J Thomalla Götz G Bendszus Martin M
Clinical neuroradiology 20200206 1
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Project description:IntroductionEmotion regulation is an important part of optimising performance and successful goal pursuit in practice-based tasks such as making music. Musicians may regulate their own emotions during the course of their musical practice in order to improve their performance and ultimately attain their practice-related goals. The specific emotions they target may depend upon their personality traits but may also relate to the nature of their goal orientation, and the interaction between the two. This study investigates whether the emotions desired by musicians in their musical practice were dependent on their personality traits and Mastery goal orientation (the desire to master musical and technical skills).MethodsVia an online questionnaire, 421 musicians completed a personality scale and answered questions relating to their mastery practice goals. They also completed emotion scales indicating how strongly they desired to increase or decrease the intensity of specific emotions when practicing.ResultsOverall, musicians preferred to up-regulate positive rather than negative emotions [paired t(420) = 58.13, p < 0.001]. Bayesian Mixed Effects models showed that personality traits affected musicians' desire to regulate specific emotions. For example, higher levels of Agreeableness predicted greater desire to increase positive but not negative emotions, whereas Extraversion predicted greater desire to increase anger [Est. = 0.05, SE = 0.03, Odds (Est. > 0) = 43.03] but not positive emotions. The inclusion of Mastery goal orientation either amplified or mitigated these effects in several cases, and also introduced new trait-emotion relationships. Findings confirm a general hedonic principle underlying the emotions musicians desired in their musical practice. However, predicted by personality traits, musicians also sometimes sought to increase the intensity of unpleasant emotions.DiscussionThese findings complement existing research that suggests that some Mastery-oriented musicians may seek an emotional state consisting of both positive and negative emotions. This and future studies on this topic may contribute to a better understanding of individual differences in emotion regulation ability as a potential aspect of individualised musical practice strategies.
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Project description:Bacterial canker disease is a major limiting factor in the growing of cherry and other Prunus species worldwide. At least five distinct clades within the bacterial species complex Pseudomonas syringae are known to be causal agents of the disease. The different pathogens commonly coexist in the field. Reducing canker is a challenging prospect as the efficacy of chemical controls and host resistance may vary against each of the diverse clades involved. Genomic analysis has revealed that the pathogens use a variable repertoire of virulence factors to cause the disease. Significantly, strains of P. syringae pv. syringae possess more genes for toxin biosynthesis and fewer encoding type III effector proteins. There is also a shared pool of key effector genes present on mobile elements such as plasmids and prophages that may have roles in virulence. By contrast, there is evidence that absence or truncation of certain effector genes, such as hopAB, is characteristic of cherry pathogens. Here we highlight how recent research, underpinned by the earlier epidemiological studies, is allowing significant progress in our understanding of the canker pathogens. This fundamental knowledge, combined with emerging insights into host genetics, provides the groundwork for development of precise control measures and informed approaches to breed for disease resistance.
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Project description:Quality assurance is one of the most important aspects of an epidemiological study, as its validity is largely determined by data quality. The mounting success of quality management in the industrial sector caused a rapid spread throughout manufacturing industries and beyond. Yet, little has been published so far on quality assurance in epidemiology. In this article we review three models for quality assurance (Juran, Donabedian and ISO 9000) and showcase how these can be brought together in one intuitive, systematic and flexible approach to quality assurance in epidemiology. The resulting Open Quality approach refers back to the three processes identified by Juran (planning, control and verification). During the planning stage, we propose a subdivision of the study process in a set of steps and a definition of quality attributes corresponding to activities in that step as suggested by the ISO approach. We refer to the Donabedian model to determine the level at which the control/monitoring should take place-structure, processes or outcomes. Along with an overview of the Open Quality approach we propose an Open Quality tool to support the definition of quality attributes, failure modes, preventive strategies, verification activities, and corrective actions, which form the backbone of the Open Quality approach.
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Project description:BackgroundIndividuals with skin-picking disorder (SPD) display reduced neural sensitivity to slow/soft touch. This functional magnetic resonance imaging (fMRI) study investigated the effects of Soft Touch Training (STT) on neural correlates of touch processing and SPD symptoms.MethodFemales with a primary diagnosis of SPD (n = 57) were randomly assigned to receive either four weeks of STT (guided soft brushing of selected skin regions) or Progressive Muscle Relaxation (PMR) training (guided tensing and relaxing of selected muscle regions). The app-assisted intervention consisted of 15-minute daily training sessions at home. Before and after the four-week intervention, the two groups participated in a standardized tactile stimulation procedure during fMRI (affective vs nonaffective touch of the forearm). Intervention-based changes in subjective and neural responses to the tactile stimulation as well as SPD severity were compared between the groups.ResultsSTT increased the pleasantness ratings for (affective) touch administered during fMRI, which was accompanied by decreased activation in the parietal operculum (PO) and supramarginal gyrus (SMG), as well as increased PO-SMG connectivity. These findings possibly reflect normalized affective touch processing due to STT. Both interventions (STT and PMR) reduced SPD severity.ConclusionsThis study demonstrated that a brief app-assisted touch training can change the experience of receiving touch from others and the associated brain activity and connectivity. Adaptations of the training relating to duration/ frequency of sessions might enhance its effectiveness.
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Project description:This article evaluates how territorial autonomy affects ethnic mobilization and conflict during regime transitions. Previous research has highlighted its conflict-inducing role during prominent transition contexts. Alternatively, it has shown its pacifying role in the "average" case, without distinguishing transition periods from stable contexts. Addressing these gaps, we argue that the de-escalatory consequences of autonomy depend on critical stabilizing factors which are themselves "muted" during transitions. We test our expectations in a cross-national analysis, covering all regime transitions between 1946 and 2017. We also revisit the 1989 transition from Communism, focusing on the role of "inherited" autonomy in the post-communist successor states. This enables us to address concerns whereby autonomy is offered to ward off transitions or whereby transitions are themselves induced by mobilization. Our findings indicate that during transitions, territorial autonomy increases the likelihood of ethnic mobilization, government concessions in response, and violent escalation where these are not forthcoming.
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