Preoperative serum chromogranin-a is predictive of survival in locoregional jejuno-ileal small bowel neuroendocrine tumors.

ABSTRACT:

Background

Small bowel neuroendocrine tumors (SB-NET) frequently metastasize to regional lymphatic or distant sites. Although most prognostication of SB-NET focuses on lymph node involvement, findings from studies of neuroendocrine tumors from other primary sites have suggested that preoperative serum chromogranin-A (CgA) levels may provide a more accurate metric.

Methods

Using the National Cancer Database (2004-2016), we analyzed patients with locoregional SB-NET who underwent curative resection including an adequate lymphadenectomy (n = 1,274). A statistically optimized cut-point was used to dichotomize CgA cohort based on preoperative serum CgA levels.

Results

We determined that a CgA ≥139 ng/mL identified patients with significantly shorter estimated mean overall

SUBMITTER: Chatani PD 

PROVIDER: S-EPMC8217103 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature