Impact of etiology on force and kinetics of left ventricular end-stage failing human myocardium.

ABSTRACT:

Background

Heart failure (HF) is associated with highly significant morbidity, mortality, and health care costs. Despite the significant advances in therapies and prevention, HF remains associated with poor clinical outcomes. Understanding the contractile force and kinetic changes at the level of cardiac muscle during end-stage HF in consideration of underlying etiology would be beneficial in developing targeted therapies that can help improve cardiac performance.

Objective

Investigate the impact of the primary etiology of HF (ischemic or non-ischemic) on left ventricular (LV) human myocardium force and kinetics of contraction and relaxation under near-physiological conditions.

Methods and results

Contractile and kinetic parameters were assessed in LV intact trabecula

SUBMITTER: Mashali MA 

PROVIDER: S-EPMC8217133 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature