Infusion reactions in natural killer cell immunotherapy: a retrospective review.

ABSTRACT:

Background aims

The use of natural killer (NK) cells as a cellular immunotherapy has increased over the past decade, specifically in patients with hematologic malignancies. NK cells have been used at the authors' institution for over 15 years. Most patients have a reaction to NK cell infusion. The authors retrospectively analyzed the reactions associated with NK cell infusions to characterize the types of reactions and investigate why some patients have higher-grade reactions than others.

Methods

A retrospective chart review of NK cell infusions was performed at the authors' institution under nine clinical protocols from 2008 to 2016. An infusion reaction was defined as any symptom from the time of NK cell infusion up to 4 h after infusion completion. The severity of infusio

SUBMITTER: Mamo T 

PROVIDER: S-EPMC8217213 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature