Genetic diversity and molecular evolution of human respiratory syncytial virus A and B.

ABSTRACT: Human respiratory syncytial viruses (RSVs) are classified into two major groups (A and B) based on antigenic differences in the G glycoprotein. To investigate circulating characteristics and phylodynamic history of RSV, we analyzed the genetic variability and evolutionary pattern of RSVs from 1977 to 2019 in this study. The results revealed that there was no recombination event of intergroup. Single nucleotide polymorphisms (SNPs) were observed through the genome with the highest occurrence rate in the G gene. Five and six sites in G protein of RSV-A and RSV-B, respectively, were further identified with a strong positive selection. The mean evolutionary rates for RSV-A and -B were estimated to be 1.48 × 10^-3 and 1.92 × 10^-3 nucleotide substitutions/site/year, respecti

SUBMITTER: Yu JM 

PROVIDER: S-EPMC8217232 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature