Use of proton pump inhibitors is associated with lower hemoglobin levels in people with cystic fibrosis.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2RAs) are commonly prescribed to people with cystic fibrosis (PwCF) to treat gastroesophageal reflux disease (GERD) and/or protect pancreatic enzymes from degradation in the stomach. Acid suppressive medications (ASMs) could theoretically reduce hemoglobin (Hgb) levels by restricting enteral iron absorption, but evidence of an association between use of ASMs and lower Hgb levels is lacking in PwCF.

Methods

We used unadjusted and covariate-adjusted generalized linear mixed models (GLMMs) to estimate the fixed effects of using versus never using ASMs on annual Hgb levels of PwCF in the U.S. Cystic Fibrosis Foundation Patient Registry (CFFPR) from 2011 to 2017.

Results

There were 9850 users

SUBMITTER: Gifford AH 

PROVIDER: S-EPMC8217294 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature