Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.

ABSTRACT:

Background

Exposure to violence (ETV) or chronic stress may influence asthma through unclear mechanisms.

Methods

Epigenome-wide association study (EWAS) of ETV or chronic stress measures and DNA methylation in nasal epithelium from 487 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Ricans study [EVA-PR]). We assessed four measures of ETV and chronic stress in children (ETV scale, gun violence, and perceived stress) and their mothers (perceived stress). Each EWAS was conducted using linear regression, with CpGs as dependent variables and the stress/violence measure as a predictor, adjusting for age, sex, the top five principal components, and SVA latent factors. We then selected the top 100 CpGs (by p value) associate

SUBMITTER: Yan Q 

PROVIDER: S-EPMC8217314 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature