Composition and function of ciliary inner-dynein-arm subunits studied in Chlamydomonas reinhardtii.

ABSTRACT: Motile cilia (also interchangeably called "flagella") are conserved organelles extending from the surface of many animal cells and play essential functions in eukaryotes, including cell motility and environmental sensing. Large motor complexes, the ciliary dyneins, are present on ciliary outer-doublet microtubules and drive movement of cilia. Ciliary dyneins are classified into two general types: the outer dynein arms (ODAs) and the inner dynein arms (IDAs). While ODAs are important for generation of force and regulation of ciliary beat frequency, IDAs are essential for control of the size and shape of the bend, features collectively referred to as waveform. Also, recent studies have revealed unexpected links between IDA components and human diseases. In spite of their importance, studies

SUBMITTER: Yamamoto R 

PROVIDER: S-EPMC8217317 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature