White Matter Microstructure in the Young Adult Brain Varies with Neighborhood Disadvantage in Adolescence.

ABSTRACT: Neighborhood disadvantage and community violence are common in poor, urban communities and are risk factors for emotional dysfunction. Emotional processes are supported by neural circuitry that includes the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, stria terminalis, and fornix. Emotional function varies with the microstructure of these white matter pathways. However, it is not clear whether the microstructure of these pathways varies with risk factors for emotional dysfunction (e.g., neighborhood disadvantage and violence exposure). Therefore, determining the relationships between neighborhood disadvantage, violence exposure, and white matter microstruct

SUBMITTER: Bell KL 

PROVIDER: S-EPMC8217337 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature