N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects.

ABSTRACT: We used proton magnetic resonance spectroscopy (¹H MRS) to quantify N-acetylaspartate (NAA) concentrations and apparent spin-spin (T2) relaxation times, which also include diffusion attenuations, in first episode and chronic psychosis patients compared to matched healthy controls. 104 patients diagnosed with psychotic disorders and 50 matched controls were scanned at 4 Tesla. ¹H MRS data were collected at four echo times (TE = 30, 90, 150 and 200 ms) using PRESS. NAA concentrations referenced to water and apparent T2 relaxation times of NAA and water were calculated. At TE = 30 ms, NAA concentration without T2 correction was significantly lower in chronic psychosis patients compared to age-matched healthy controls (p = 0.013, N = 61 and 26, respectively) but normal in

SUBMITTER: Kuan E 

PROVIDER: S-EPMC8217341 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature