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Membrane Exporters of Fluoride Ion.

ABSTRACT: Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F^-), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years toward understanding the microbial response to cytoplasmic accumulation of F^-, with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride: the CLC^F family of F^-/H⁺ antiporters and the Fluc/FEX family of F^- channels.

SUBMITTER: McIlwain BC

PROVIDER: S-EPMC8217344 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Membrane Exporters of Fluoride Ion.

McIlwain Benjamin C BC Ruprecht Michal T MT Stockbridge Randy B RB

Annual review of biochemistry 20210125

Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F<sup>-</sup>), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years toward understanding the microbial response to cytoplasmic accumulation of F<sup>-</sup>, with a special emphasis on the structure ...[more]

PMID: 33492991

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