Efficacy and Safety of Anti-TNFα Therapy for Uveitis Associated with Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

To investigate the efficacy and safety of anti-TNFα therapy in patients with juvenile idiopathic arthritis associated uveitis (JIA-U).

Methods

Embase, PubMed, Cochrane Library, and Web of Science were systematically searched for studies reporting anti-TNFα treatment in patients with JIA-U. The primary outcome was the control of intraocular inflammation (CII). The pooled proportion of CII was assessed by the random-effects method when I² > 50%, otherwise, by the fixed-effect method. This study was registered with PROSPERO (CRD42020161749).

Results

Three randomized clinical trials (RCTs), twelve case series, three retrospective cohort studies, and three case reports were identified. A total of 399 patients were receiving anti-TNFα therapy, of whi

SUBMITTER: Li Y 

PROVIDER: S-EPMC8217376 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature