Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.

ABSTRACT: Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood-brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial str

SUBMITTER: Farajzadeh Khosroshahi S 

PROVIDER: S-EPMC8217506 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature